Individuals with chronic renal failure and uremia show a constellation of symptoms, signs, and laboratory abnormalities additionally to those observed in acute kidney injury. This reflects the long-standing and progressive nature of their renal impairment and its results on many kinds of tissues.

Causes like pylonephrosis, nephrosclerosis, glumerolunephritis, obstructive kidney conditions due to blocking kidney stones and birth anomaly- congenital malformations, effects of some drugs especially when abused and over use of pain killer have been implicated in the chronic renal failure disease.

For which ever cause, the result is always same- retention of dangerous waste products/fluids of nitrogenous bases, causing electrolyte imbalance and death if unchecked.

In most cases where chronic renal failure is diagnosed, the exact cause of the disease is usually unknown and treatment is aimed at management of the disease. Some of the common signs found in cats with CRF are a poor appetite, weight loss, and dehydration. You will notice an increase in thirst in the affected cat as well as excessive urination (CRF cats increasingly lose the ability to concentrate urine and will drink and urinate more and more often).

The management of chronic renal failure consists of treatment of the underlying cause if possible, aggressive treatment of high blood pressure and other symptoms, liquid and diet control, cessation of smoking, and finally, with end-stage disease, resorting to dialysis or a kidney transplant.
The Ayurvedic treatment of chronic renal failure is based on three principles: (i) treating the damaged kidneys (ii) treating the body tissues (dhatus) which make up the kidneys and (iii) treating the known cause.

CRF has many causes including glumerolunephritis, nephrosclerosis, obstructive kidney diseases such as kidney stones and birth defects, diabetes mellitus and systemic lupus erythematosus, and most recently discovered illicit drugs and excessive analgesic use.

Regardless of the cause, the result will be the same: retention of nitrogenous wastes, fluid imbalances, electrolyte deficiencies and more. All of which affect multiple body systems.

Traditional Ayurvedic medicines which are useful in chronic renal failure are: Gokshuradi Guggulu, Punarnava Guggulu, Punarnavadi Qadha(decoction), Arogya Vardhini, Chandraprabha Vati, Gomutra Haritaki, Surya Kshar and Yava Kshar. Single herbal medicines useful in this condition are: Gokshur (Tribulus terrestris), Punarnava (Boerhaavia diffusa), Shilajit (Purified Bitumen), Varun (Crataeva nurvala), Manjishtha (Rubia cordifolia),Saariva (Hemidesmus indicus), Apamarg (Achyranthus aspera) and Haritaki (Terminalia chebula).

The first evidence of difficulty is usually loss of normal energy and increased fatigue on exertion. For example, the child may prefer quiet, passive activities rather than participation in more active games and outdoor play. The child is usually somewhat pale, but it is often so inconspicuous that the change may not be evident to parents or others. Sometimes the blood pressure is elevated.

Diet and intravenous fluids are the most common therapies for cats with CRF. Dietary management means feeding a diet lower in protein, salt and phosphorous. Reducing these things will help the kidneys function better. A lower protein diet takes some of the burden off the kidneys for filtering waste, as protein molecules tend to be larger and create a heavier burden on the kidney.